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Title: Assessing Risk Factors for Obesity Between Childhood and Adolescence: I. Birth Weight, Childhood Adiposity, Parental Obesity, Insulin, and Leptin.
Subject Terms: INDIAN children; OBESITY in children
Source: Pediatrics, Aug2002 Part 1, Vol. 110 Issue 2, p299, 8p, 1 graph
Authors: Salbe, Arline D.; Weyer, Christian; Lindsay, Robert S.; Ravussin, Eric; Tataranni, P. Antonio
Abstract: ABSTRACT Objective. To assess the effects of body weight, body composition, parental obesity, and metabolic variables on the development of obesity in a large cohort of 5-year-old Native American children with a high propensity for obesity. Methods. During the summer months of 1992 to 1995 and again 5 years later, 138 (65 boys and 73 girls) 5-year-old Pima Indian children were studied. Height; weight; body composition; parental obesity; and fasting plasma insulin, glucose, and leptin concentrations were determined at baseline and follow-up. Linear regression models were used to assess the effect of the baseline variables on the development of obesity. Results. At both 5 and 10 years of age, Pima Indian children were heavier and fatter than an age- and gender-matched reference population. All anthropometric and metabolic variables tracked strongly from 5 to 10 years of age (r ¡Ã 0.70). The most significant determinant of percentage of body fat at 10 years of age was percentage of body fat at 5 years of age (R©÷ = 0.53). The combined effect of high maternal body mass index, elevated fasting plasma leptin concentrations, and low fasting plasma insulin concentrations at baseline explained an additional 4% of the...
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